Asenapine is dosed at which range?

• A. 5-10 mg BID
• B. 2-5 mg daily
• C. 10-20 mg BID
• D. 1-2 mg daily

Answer: (A)

Dosing asenapine is usually 5 mg to 10 mg given twice daily. Starting at 5 mg twice daily lets you gauge tolerability, then you can move up to the typical target of 10 mg twice daily. The overall daily maximum is 20 mg, so doses above 10 mg per administration would push daily intake past the recommended limit. The other ranges would either be too low to achieve efficacy or exceed the maximum daily dose. Remember, these are sublingual tablets, so place them under the tongue and let them dissolve, avoiding eating or drinking for about 10 minutes after administration to ensure proper absorption.