Dosing for Haloperidol decanoate is typically in the range of?

• A. 150-300 mg
• B. 100-150 mg
• C. 50-100 mg
• D. 300-450 mg

Answer: (A)

Haloperidol decanoate is a long-acting injectable, so the goal is to maintain therapeutic brain concentrations over a 4-week period with one dose. For most adults on maintenance therapy, the standard injection falls in the 150–300 mg range every 4 weeks. This dose provides a balance between effective symptom control and the risk of extrapyramidal side effects that increases with higher amounts. Doses well below this, like 50–100 mg, are usually subtherapeutic for maintenance and can lead to relapse. Doses in the 300–450 mg bracket push the risk of EPS and other adverse effects higher and are not considered routine for most patients. Dosing is tailored to prior oral exposure, tolerability, and response, with careful monitoring for movement disorders and other side effects.