Dyskinesias and chorea are movement disorders treated with which combination of antipsychotics?

• A. Haloperidol
• B. Risperidone
• C. Haloperidol and Risperidone
• D. Chlorpromazine

Answer: (C)

Movement disorders like dyskinesias and chorea can be helped by blocking dopamine D2 receptors in the brain’s motor circuits. Haloperidol is a potent D2 antagonist, and risperidone also blocks D2 receptors (with additional serotonergic effects). When a single antipsychotic doesn’t adequately control severe, involuntary movements, using both can provide stronger D2 blockade and greater suppression of these movements. This approach is typically reserved for refractory cases, because combining antipsychotics raises the risk of extra-pyramidal symptoms and other adverse effects, so it requires careful monitoring and expert oversight. In practice, this combination may be used in serious chorea (for example in Huntington’s disease) when monotherapy fails to achieve sufficient control.