Grapefruit juice should be avoided with which drug due to CYP3A4 inhibition?

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Multiple Choice

Grapefruit juice should be avoided with which drug due to CYP3A4 inhibition?

Explanation:
Grapefruit juice can block intestinal CYP3A4, which reduces the metabolism of many drugs and raises their blood levels. Pimozide is metabolized by this enzyme, so grapefruit juice can significantly increase its exposure. That higher exposure raises the risk of QT prolongation and dangerous arrhythmias, making grapefruit juice something to avoid with pimozide. The other statements don’t fit because grapefruit juice does not reduce pimozide side effects, it does affect (not leave unchanged) its metabolism, and it does not enhance metabolism—instead, it inhibits it.

Grapefruit juice can block intestinal CYP3A4, which reduces the metabolism of many drugs and raises their blood levels. Pimozide is metabolized by this enzyme, so grapefruit juice can significantly increase its exposure. That higher exposure raises the risk of QT prolongation and dangerous arrhythmias, making grapefruit juice something to avoid with pimozide. The other statements don’t fit because grapefruit juice does not reduce pimozide side effects, it does affect (not leave unchanged) its metabolism, and it does not enhance metabolism—instead, it inhibits it.

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