Hyperprolactinemia is associated with D2 occupancy in what range?

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Multiple Choice

Hyperprolactinemia is associated with D2 occupancy in what range?

Explanation:
Dopamine acting at D2 receptors on pituitary lactotrophs normally keeps prolactin levels in check. When a drug blocks these receptors, prolactin rises, and the amount of receptor occupancy needed to see this rise is around half to three-quarters. So, a D2 occupancy roughly in the 50-75% range is what tends to produce hyperprolactinemia. Occupancies much lower generally don’t push prolactin up, while higher occupancies (especially well above 75%) are more likely to cause extrapyramidal symptoms as well.

Dopamine acting at D2 receptors on pituitary lactotrophs normally keeps prolactin levels in check. When a drug blocks these receptors, prolactin rises, and the amount of receptor occupancy needed to see this rise is around half to three-quarters. So, a D2 occupancy roughly in the 50-75% range is what tends to produce hyperprolactinemia. Occupancies much lower generally don’t push prolactin up, while higher occupancies (especially well above 75%) are more likely to cause extrapyramidal symptoms as well.

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