Late onset schizophrenia is characterized by which onset pattern?

• A. Onset only in adolescence
• B. Late onset with a second midlife peak
• C. Onset only after 65
• D. Onset after puberty

Answer: (B)

The key idea is that schizophrenia can show different age-at-onset patterns. While many cases begin in adolescence or early adulthood, late-onset schizophrenia can occur after midlife, and epidemiologic data sometimes show a second wave of onset around midlife. That combination—onset after 45 with a notable midlife peak—best describes late onset with a second midlife peak.

Other patterns don’t fit as well: onset only in adolescence reflects the typical early-onset form, not the late-onset pattern. Onset only after 65 is too narrow and not the standard description of late-onset schizophrenia, which more commonly includes a broader late-adult range and can include a midlife peak. Onset after puberty covers a wide range that includes early onset; it doesn’t capture the late-onset bimodal pattern.