Neutropenia/Agranulocytosis Definition: ANC below which value?

• A. ANC < 1.5 x10^9
• B. ANC < 2.0 x10^9
• C. ANC < 0.5 x10^9
• D. ANC < 3.0 x10^9

Answer: (A)

Absolute neutrophil count (ANC) is the measure used to gauge how many neutrophils are circulating, which reflects the body’s ability to fight infections. Neutropenia is defined as ANC falling below about 1.5 x 10^9/L. When ANC dips under this level, infection risk rises and clinicians monitor more closely, consider adjusting treatments that suppress the marrow, and may implement supportive measures if needed. Agranulocytosis is a more severe drop, typically defined as ANC below about 0.5 x 10^9/L, and it represents a higher-risk state that often requires urgent management.

The other thresholds don’t define neutropenia. An ANC around 2.0 or 3.0 x10^9/L is within or above the normal range, while 0.5 x10^9/L marks agranulocytosis rather than the broader neutropenia category.