The regimen '50 mg BID increased by 50 mg/day to a goal of 200 mg BID' is associated with which antipsychotic?

• A. Quetiapine
• B. Risperidone
• C. Olanzapine
• D. Asenapine

Answer: (A)

This pattern shows how quetiapine is titrated in schizophrenia. You start at a low dose—50 mg twice daily—and increase about 50 mg per day until reaching a practical target dose, commonly around 400 mg per day (200 mg twice daily). This gradual ramp helps minimize sedation, orthostatic effects, and other tolerability issues while allowing symptomatic improvement to emerge.

Risperidone, olanzapine, and asenapine have different starting points and typical titration paths. For example, risperidone usually begins around 0.5–1 mg twice daily and is titrated more gradually toward overall daily doses that are often well below 400 mg/day. Olanzapine is typically started at 5–10 mg daily and titrated up to about 15–20 mg daily. Asenapine commonly uses 5–10 mg twice daily, not the 50 mg/day incremental pattern described here.