Tourette's Syndrome treatment commonly includes which medications?

• A. Haloperidol
• B. Pimozide
• C. Haloperidol and Pimozide
• D. Chlorpromazine

Answer: (C)

Tourette syndrome with troublesome tics is often treated with dopamine D2 receptor antagonists, drugs that blunt dopaminergic signaling in the brain circuits that control movement to reduce tic frequency and severity.

Haloperidol and pimozide are potent D2 blockers with strong evidence supporting their effectiveness in suppressing tics. Because of their robust tic-reducing effects, they are commonly used in clinical practice. However, each comes with potential side effects: haloperidol can cause extrapyramidal symptoms and tardive dyskinesia, while pimozide can prolong the QT interval and requires cardiac monitoring. Chlorpromazine also helps some patients but is generally less favored today for tic control due to more sedating effects and other risks, making haloperidol and pimozide the more typical choices in many treatment plans.