What advisement should be given on the day of Olanzapine long-acting IM injection?

• A. Eat a high-fat meal
• B. Exercise immediately after
• C. Do not drive or use heavy machinery day of injection
• D. Take with alcohol

Answer: (C)

The safety concern with olanzapine long-acting injectables is the potential for lingering sedation or post-injection delirium/sedation syndrome. Because these effects can occur soon after the shot, the advised plan is to avoid activities requiring alertness on the day of injection, especially driving or operating heavy machinery. This helps prevent accidents if sedation or confusion occurs after the injection. In practice, patients are also observed in clinic for several hours after administration to monitor for PDSS and to ensure they can go home safely with someone to assist them. The other options don’t address this safety risk: a high-fat meal isn’t required, exercising immediately after isn’t protective and can worsen dizziness, and consuming alcohol would heighten sedation and impairment.