What is Lurasidone dosing in moderate hepatic impairment?

• A. 5-15 mg/day
• B. 20-80 mg/day
• C. 40-120 mg/day
• D. 80-160 mg/day

Answer: (B)

In moderate hepatic impairment, the body's ability to clear lurasidone is reduced because the drug is extensively metabolized by the liver. That means exposure to the drug can become higher if the same amount is given as in people with normal liver function, so the dose needs to be lowered and capped to balance efficacy with safety. The dosing guidance for this level of liver impairment allows a daily range of 20 to 80 mg, taken with a meal to optimize absorption. A typical approach is to start at 20 mg once daily with food and, based on how well the patient responds and tolerates it, increase by small amounts, up to a maximum of 80 mg per day. Always remember to take lurasidone with at least about 350 calories of food to ensure the best absorption. This strategy helps maintain effective levels while reducing the risk of adverse effects in those with moderate liver dysfunction.