Which combination is used for Tourette's syndrome according to the material?

• A. Haloperidol
• B. Pimozide
• C. Haloperidol and Pimozide
• D. Chlorpromazine

Answer: (C)

Tourette's symptoms respond to reducing dopaminergic signaling in the motor circuits, so potent dopamine D2 blockers are effective for tic suppression. Haloperidol and pimozide both act as strong D2 antagonists and have long tracks of use in treating Tourette's, so they’re known to reduce tic frequency and intensity. When one drug doesn’t fully control the tics, combining two agents can provide greater symptom relief by targeting the dopaminergic system more robustly, sometimes allowing lower doses of each drug. This approach is considered in refractory cases where tic control is insufficient with a single agent. At the same time, using two potent antipsychotics increases the risk of extrapyramidal side effects and, with pimozide, serious cardiac effects like QT prolongation, so such therapy must be pursued with careful monitoring and dose adjustments. In the material you’re studying, the combination of haloperidol and pimozide is described as a treatment option for Tourette's, which is why it’s identified as the used combination in this context.