Which drug is listed as an adjunctive treatment for MDD?

• A. Clozapine
• B. Haloperidol
• C. Lurasidone
• D. Paliperidone

Answer: (A)

Adjunctive antipsychotic therapy is used to boost antidepressant response in treatment-resistant major depressive disorder or when psychotic features are present. Clozapine is an antipsychotic with a primary use in treatment‑resistant schizophrenia and carries a significant safety burden, including the need for regular blood monitoring due to risk of agranulocytosis. Because of its safety profile and the lack of strong evidence supporting its use as an augmentation in unipolar MDD, it is not a typical choice for adjunctive therapy in MDD. Other antipsychotics (like aripiprazole or quetiapine) have more robust data for augmentation in depression, while haloperidol is generally avoided due to extrapyramidal risks and the other two options are primarily indicated for schizophrenia or bipolar depression.