Which drug is listed for treating a manic episode in bipolar disorder?

• A. Clozapine
• B. Lurasidone
• C. Quetiapine
• D. Haloperidol

Answer: (D)

In acute mania, the priority is rapid stabilization of agitation, psychosis, and elevated mood. Haloperidol is a potent, fast-acting antipsychotic that quickly dampens manic symptoms by blocking dopamine D2 receptors, making it effective for rapid control in inpatient or emergency settings. Its quick onset and solid evidence base for acute mania often lead to it being listed as a treatment option for a manic episode, sometimes used alone or with a mood stabilizer or a benzodiazepine for severe agitation.

Other drugs on the list can be used in bipolar disorder, but they aren’t as consistently emphasized for rapid, acute mania. Clozapine is generally reserved for treatment-resistant schizophrenia, lurasidone is indicated more for bipolar depression (and schizophrenia) rather than acute mania, and while quetiapine can treat mania, haloperidol’s speed and established role in acute stabilization often make it the preferred listed option in many guidelines and exams.