Which effect may be observed with antipsychotic use in the third trimester?

• A. Maternal hypotension
• B. Neonatal jaundice
• C. Increased fetal movement
• D. Postpartum hemorrhage

Answer: (A)

Antipsychotics can lower maternal blood pressure due to their alpha-1 adrenergic receptor–blocking effects. This blockade causes peripheral vasodilation and reduced systemic vascular resistance, which can manifest as maternal hypotension, especially in the third trimester when blood pressure changes during labor are closely monitored. If hypotension is significant, it can affect uteroplacental perfusion, making this an important observed effect in late pregnancy.

Other listed effects do not fit as typical direct consequences of antipsychotic use in the third trimester. Neonatal jaundice is not a characteristic, specific effect of these drugs during late pregnancy. Increased fetal movement is not expected and would be more consistent with stimulants or certain disorders rather than an antipsychotic. Postpartum hemorrhage is not a known direct pharmacologic effect of antipsychotics and is more related to obstetric factors and other uterotonic or anticoagulant influences.