Which two drugs are named for acute agitation treatment?

• A. Olanzapine, ziprasidone
• B. Clozapine
• C. Haloperidol
• D. Paliperidone

Answer: (A)

Rapid tranquilization of acute agitation relies on antipsychotics that work quickly when given by intramuscular route. Olanzapine and ziprasidone are both available as IM injections and are commonly used in emergency or inpatient settings to rapidly calm agitated patients with psychosis or mania. Their quick onset and practical IM forms make them top choices for acute agitation management, offering effective control with a different safety profile than older agents like haloperidol. While haloperidol is also used for agitation, these two are particularly associated with rapid treatment in this context, and the others listed are not favored for immediate agitation control due to slower onset or higher risk profiles (for example, clozapine isn’t used acutely and paliperidone isn’t a first-line agent for rapid agitation).